Jie-Ru Wei

Tmlhe deficiency induces neurodevelopmental dysfunction and synaptic excitatory/inhibitory imbalance linked to autism-like phenotypes in zebrafish.

It is demonstrated that tmlhe deficiency disrupts carnitine biosynthesis, impairing energy and glycerophospholipid metabolism, which is critical for early neurogenesis, which may lead to impaired neural development and a synaptic E/I imbalance, ultimately causing ASD-like phenotypes.