Noninvasive Characterization of Tumor Heterogeneity in Locally Advanced Nasopharyngeal Carcinoma: From Progression-Free Survival Prediction to Biological Correlates.
BACKGROUND Locally advanced nasopharyngeal carcinoma (LA-NPC) shows substantial variability in progression-free survival (PFS) despite radiotherapy-based treatment. Clinical factors and conventional radiomics may not adequately characterize the spatial organization of intratumoral heterogeneity. Whether topology-aware...