Conventional tumor-targeted nanocarriers remain limited by heterogeneous intratumoral distribution, which arises from abnormal tumor vasculature, dense extracellular matrix barriers, and spatially variable receptor expression. These biological barriers restrict deep tumor penetration and prevent homogeneous nanocarrier...
Jin-Yan Liu, Zhi-Jie Fang, Wei-Qing Yue et al.· Journal of materials chemist...· 0 citations
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by significant treatment challenges and poor prognosis. Traditional therapies such as surgical resection, radiotherapy, and chemotherapy often suffer from limitations including insufficient therapeutic specifi...
Abstract Insufficient tumor accumulation and heat shock protein (HSP)-mediated adaptive resistance remain major barriers to effective cancer therapy. Here, a cysteine-inspired conjugated polymer photosensitizer (CP-PCys) was developed to integrate enhanced tumor accumulation, hydrogen sulfide (H2S) generation, photodyn...
Yan Yuan, Zhi-Jie Fang, Wei-Qing Yue et al.· ACS Applied Materials and In...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.