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Sep 2026

An amino acid cluster-inspired nanoplatform exhibits LAT1-mediated cell targeting for tumor delivery.

Conventional tumor-targeted nanocarriers remain limited by heterogeneous intratumoral distribution, which arises from abnormal tumor vasculature, dense extracellular matrix barriers, and spatially variable receptor expression. These biological barriers restrict deep tumor penetration and prevent homogeneous nanocarrier...

Jin-Yan Liu, Zhi-Jie Fang, Wei-Qing Yue et al. · 0 citations
Open access Sep 2026

Programmable Organic A2S-TT NPs for NIR-II/Photoacoustic Imaging-Enabled Precision Therapy

Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer characterized by significant treatment challenges and poor prognosis. Traditional therapies such as surgical resection, radiotherapy, and chemotherapy often suffer from limitations including insufficient therapeutic specifi...

Wei Sang, Yi-Jun Huang, Jia-Hui Wen et al. · 0 citations
#protein folding Sep 2026

Cysteine-Inspired Photosensitizer with Efficient Tumor Accumulation Enables Thermoresistance Reversal for Reciprocal Enhancement of Photodynamic-Photothermal Therapy.

Abstract Insufficient tumor accumulation and heat shock protein (HSP)-mediated adaptive resistance remain major barriers to effective cancer therapy. Here, a cysteine-inspired conjugated polymer photosensitizer (CP-PCys) was developed to integrate enhanced tumor accumulation, hydrogen sulfide (H2S) generation, photodyn...

Yan Yuan, Zhi-Jie Fang, Wei-Qing Yue et al. · 0 citations

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