Author

Jie Li

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Open access Jul 2026

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to global swine industry, yet the immune mechanisms underlying protective vaccination are incompletely understood. Here, we applied integrated single‐cell RNA sequencing and T cell receptor (TCR) profiling to characterize immune...

C. Kong, Siang Chen, Maolin Li et al. · Advancement of science · 0 citations

Jul 2026

An E2 Glycoprotein-based Recombinant Subunit Vaccine Confers Protective Immunity Against Classical Swine Fever Virus in Piglets.

CSFV is a highly contagious disease threatening global pig production. Conventional live vaccines protect effectively but prevent serological differentiation between infected and vaccinated animals-undermining surveillance and eradication efforts. Therefore, it is crucial to develop a new generation of safe and effecti...

Zhiqiang Li, Pengfei Fang, Yanpeng Dong et al. · Microbial Pathogenesis · 0 citations