Author

Jie-Jing Zhang

2 papers indexed here

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Open access Sep 2026

An Interpretable Multimodal Machine-Learning Model for Predicting Cognitive Impairment from Routine MRI: A Study with External Validation

Existing MRI-based prediction models for cognitive impairment often rely on a single biomarker or simply compare algorithms, act as black boxes, and lack external validation, which limits their clinical translation. We developed and externally validated an interpretable multimodal machine-learning model that classifies...

Xiu-Pan Chen, Bao-Wen Zhang, Meng-Die Li et al. · Bioengineering · 0 citations

Open access Jul 2026

Glymphatic dysfunction mediates inflammation-driven vascular burden and cognitive decline in cerebral small vessel disease.

Inflammation drives CSVD progression and cognitive decline primarily through the disruption of NVC and glymphatic clearance mechanisms, highlighting glymphatic dysfunction as a critical mediator of inflammation-related structural brain damage.

Yi-Lei Chen, Jie-Jing Zhang, Ying-Jie Kang et al. · Neurobiology of Disease · 2 citations