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Author

Jie Hu

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Review Open access Oct 2026

Microbiome signatures and mechanistic pathways in pediatric obesity: from early-life risk to precision interventions.

BACKGROUND The gut microbiota is increasingly recognized as a modulator of metabolic health in children, influencing nutrient absorption, immune tone, epithelial barrier function, and energy homeostasis. This review summarizes current evidence on microbial signatures and mechanistic pathways associated with pediatric o...

Shan-Shan Xie, Jie Hu, Wei Zhou et al. · 0 citations
Review Open access Sep 2026

Post-translational modification in hepatocellular carcinoma resistance: molecular mechanisms and therapeutic targeting

This review systematically summarizes the molecular mechanisms and common pathways through which PTMs contribute to therapeutic resistance in liver cancer, explores PTM-mediated mechanism underlying tumor persistence and distant recurrence, andamines how PTM-targeted strategies may reverse resistance.

Si-Min Feng, Jie Hu, Xiao-Xi Guo et al. · 0 citations
Review Open access Aug 2026

The gut microbiome organ

This review synthesizes current mechanistic and translational evidence to conceptualize the gut microbiome as an organ‐like functional system, delineate its structural and functional organization, and propose a framework for mapping, modeling, and therapeutically targeting microbiome‐derived circuits to support precisi...

Yang Bi, Wei-Bin Song, Maria Glymenaki et al. · 0 citations

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