Aug 2026
GSDMD-mediated pyroptosis in the dorsal hippocampus is implicated in morphine-induced reward memory in mice.
It is demonstrated that morphine exposure selectively activates GSDMD-mediated pyroptotic signaling in the dorsal hippocampus (dHip), identifying neuronal pyroptosis as a previously unrecognized mechanism associated with morphine-associated reward memory and position GSDMD as a potential therapeutic target that warrants further investigation for mitigating opioid-induced maladaptive plasticity.
Dongyu Yu, Xi-xi Yang, Xiaoyun Yang et al.
· Neuropharmacology · 0 citations