Jia-Xu Hong

Nanomicelles self-assembled using cyclosporine A-hyaluronic acid conjugates for dry eye disease treatment.

Dry eye disease is a chronic inflammatory disorder of the ocular surface in which tear film instability and hyperosmolarity perpetuate a self-sustaining cycle of epithelial damage and inflammation; however, the therapeutic efficacy of topical cyclosporine A (CsA), a mainstay of treatment, is severely limited by rapid t...

Mucoadhesive recombinant human catalase for dry eye disease: From protein engineering to first-in-human study.

BACKGROUND Oxidative stress caused by excess reactive oxygen species (ROS) plays a key role in the progression of dry eye disease (DED), yet no approved DED therapy directly eliminates ROS. Here, we develop an antioxidant biologic with enhanced ocular-surface retention by thiol engineering of recombinant human catalase...

Efficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.