Author

Jia-Xing Zhang

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Open access Oct 2026

A Dual-Functional Magnetic Nanoparticle for Rapid Extraction and Targeted Tumor Delivery of Tiancimycin

Anthraquinone-fused enediynes (AFEs) are a class of microbial natural products with remarkable cytotoxicity and exhibit promising application prospects in tumor therapy. Taking tiancimycins (TNMs) as an example, this class of compounds holds great potential against triple-negative breast and liver cancers. However, the...

Cheng-Yu Zhang, Peng Zhong, Da-Xin Zhao et al. · Molecules · 0 citations

#protein folding Sep 2026

Balanced regulation of UvsX activity and thermostability based on active learning.

A directed engineering strategy is employed combining energy-based screening and protein language models to obtain a triple mutant, TIG, which enhances residue flexibility and remodels the ATP-binding pocket, thereby improving DNA-binding pathway connectivity and strengthening the coupling between ATP hydrolysis and DN...

Ling-Song Li, Lin Zhang, Dong-Xia Li et al. · International Journal of Bio... · 0 citations

Jul 2026

Rational design of IsPETase variant toward efficient poly(ethylene terephthalate) ambient degradation.

The accumulation of poly(ethylene terephthalate) (PET) waste in the environment poses a severe ecological threat. While extensive research has focused on high-performance PET degradation by thermophilic enzymes, PET hydrolases are efficient under lower-temperature conditions, which would better align with green and ene...

Jiaxing Zhang, Yu Zhou, Baoyu Zhang et al. · Bioresource Technology · 0 citations