Author

Jiarong Guo

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#protein folding Open access Oct 2026

Systematic Screening of Reference Genes for qPCR in Procambarus clarkii: RPL13a Shows Stable Expression Under Non-Ionic Ammonia Stress and Multiple Experimental Conditions

Real-time quantitative PCR (qPCR) is a key technique for elucidating the mechanisms underlying environmental stress responses in aquatic animals, and its accuracy relies heavily on stable reference genes for data normalization. In this study, histopathological examination revealed alterations in the gill, hepatopancrea...

Xiu-Dan Yuan, Xing Tian, Yuan-Yuan Liu et al. · Biology · 0 citations

Aug 2026

Network pharmacology-based identification and validation of novel vaccine candidates against brucellosis.

The development of a multi-epitope messenger RNA (mRNA) vaccine candidate targeting Brucella melitensis, the most pathogenic species responsible for human brucellosis is reported, establishing a promising platform for Brucella vaccine development warranting further evaluation in large animal models and human clinical t...

Zhi-Heng Dong, Sha Li, Jiarong Guo et al. · Research in Veterinary Scien... · 0 citations

Open access Aug 2026

Integrated multi-omics strategy for screening novel protective antigens against Brucella melitensis and analysis of their immunogenicity

Through multi-omics integration analysis, this study successfully identified a novel candidate antigen, BMEI1943, with strong Th1-type immunogenicity, providing an experimental basis for the development of safe and efficient subunit vaccines against brucellosis.

Zhi-Heng Dong, Sha Li, Jiarong Guo et al. · Brazilian Journal of Microbi... · 0 citations