Author

Jian-Ping Ding

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Aug 2026

Cryo-EM structure of the WDR11-FAM91A1-C17orf75 complex involved in retrograde trafficking.

Functional analyses demonstrate that C17orf75 is indispensable for the proper intracellular localization of the acidic-cluster-containing cargo proteins CI-MPR, KIAA0319L, and VAMP4 and establish C17orf75 as an integral component of the WFC complex in endosome-to-TGN trafficking.

Yifan Zhang, Zhi-Min Liu, Zi-Rong Chen et al. · Structure · 1 citation

Open access Aug 2026

Structure and enzymatic properties of human retroviral-like aspartic protease 1 and functional roles of disease-associated mutations.

Structural analysis reveals that ASPRV1-14 possesses distinctly hydrophobic S2/S2' pockets, dictating a strict requirement for hydrophobic residues at the P2/P2' positions of substrates and explaining its resistance to most HIV-1 PR inhibitors, except indinavir.

Xueqian Feng, Zi-Lian Chen, Chao Lan et al. · Acta Biochimica et Biophysic... · 0 citations