Sepsis-associated acute kidney injury (SA-AKI) presents a significant challenge in critical care, largely due to the multifaceted nature of renal injury stemming from interconnected disturbances in inflammation, metabolism, microcirculation, mitochondrial function and programmed cell death, rather than arising from a singular dominant pathway. Increasing evidence indicates that apoptosis, pyroptosis, ferroptosis, necroptosis and autophagy-related responses function as an integrated yet heterogeneous cell death network, characterized by extensive crosstalk, compensatory signaling and disease stage-dependent regulation. The present review uses an integrated cell death network framework for SA-AKI, rather than simply summarizing individual cell death pathways or sequentially cataloguing diet-related small molecules. Current evidence was synthesized by organizing shared regulatory nodes according to their mechanistic roles, including upstream drivers, amplifiers or permissive states, context-dependent modifiers, and terminal execution mechanisms. Focus is placed on mitochondrial dysfunction, redox-iron imbalance, NF-κB-dependent inflammatory activation, inflammasome priming, failures in autophagy/mitophagy and immunometabolic stress. Furthermore, the present review explores how diet-related small molecules may influence these shared injury conditions, differentiating between food-derived phytochemicals, nutritional compounds, microbiota-derived metabolites and intensive care unit-based antioxidant or vitamin regimens. The potential efficacy of these compounds may derive less from their ability to selectively inhibit isolated death programs and more from their capacity to reshape common upstream environments that allow multiple death pathways to manifest. Finally, major translational barriers are discussed, including limited bioavailability, uncertainty surrounding active metabolites, altered pharmacokinetics during sepsis, disease-stage specificity, renal target exposure and inter-patient heterogeneity. An exposure-aware and endotype-guided framework is proposed for the future evaluation of diet-related small molecules in the context of SA-AKI.
Lin Song, Ai-Feng He, Wei Jiang et al.· International Journal of Mol...· 0 citations
Long COVID is frequently associated with neuropsychiatric symptoms, including depression, anxiety, and fatigue, which can substantially impair daily functioning and place a considerable burden on healthcare systems worldwide. Although research in this area is expanding rapidly, no comprehensive bibliometric synthesis has characterized the field’s conceptual shifts, critical knowledge gaps, and emerging research directions. This study aimed to map the intellectual evolution and current landscape of research on Long COVID and mental health to inform future clinical and scholarly efforts.
We conducted a bibliometric analysis of publications indexed in the Web of Science Core Collection from January 1, 2019, to July 20, 2025. The search strategy combined terms related to Long COVID and mental health. Following title and abstract screening, 1,464 eligible articles were analyzed using CiteSpace for burst detection and timeline visualization, VOSviewer for network mapping of countries, institutions, authors, and keywords, and Excel for trend analysis. Inclusion criteria required original research or reviews published in English.
Annual publication output increased rapidly, with growth beginning to level off after 2023. The United States and England accounted for the largest shares of publications. However, citation impact was not directly proportional to publication volume, highlighting the importance of highly influential institutional research hubs. The core journals spanned clinical medicine and public health, reflecting the interdisciplinary nature of the field. Thematic analyses showed that research fronts have expanded beyond depression and anxiety to include neurocognitive impairment, neuroinflammatory mechanisms, and the psychosocial consequences of prolonged disability.
This is the systematic bibliometric analysis to map the intellectual structure and thematic evolution of research on Long COVID and mental health. The field has progressed from broad descriptions of psychological distress to syndrome-specific, mechanistic, and interventional investigations, providing a framework for future research priorities. Depression, anxiety, and fatigue remained central research themes, reflecting their persistent clinical burden and continued importance as research priorities.
