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Author

Jiangjiang Qin

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Review Open access Oct 2026

Anti-inflammatory drug discovery from medicinal plants: from molecular targets to therapeutic paradigms

Chronic inflammation is a central driver of diverse human diseases, including autoimmune, metabolic, neurodegenerative, and cardiovascular disorders. Although current anti-inflammatory therapies have substantially improved disease control, important unmet needs remain because of incomplete or variable responses, long-t...

Ye Wu, Ji-Yuan Zhang, Qing-Yi Xiong et al. · 0 citations
Open access Aug 2026

Discovery of a Potent and Selective KRAS G12D Degrader based on PROTAC Degradation.

This work designed and synthesized 20 novel KRAS G12D PROTACs based on the MRTX1133 derivative and found that compound VI-1 exhibited significant KRAS G12D degradation activity in PANC-0203 cells, achieving 69% effective degradation at 10 μM.

Lili Jiang, Wenyan Yang, Yan-Qing Liu et al. · 0 citations

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