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Jiang-Wei Chen

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Sep 2026

DRAM1 activates microglial pyroptosis and neuroinflammation through TMEM9-mediated lysosomal membrane permeabilization after spinal cord injury.

Findings reveal that DRAM1 promotes microglial pyroptosis and neuroinflammation after SCI via the TMEM9-dependent induction of LMP and autophagic flux impairment, with its expression tightly regulated by IGF2BP3 in an m6A-dependent manner.

Zhi-Chao Xiong, Guang-Kui Yan, Jin-Fa Wu et al. · 0 citations

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