C2,C3-unsubstituted indoles are privileged scaffolds in medicinal chemistry, yet their direct assembly from simple C2 feedstocks remains a longstanding synthetic challenge. Herein, we report an example of Y(OTf)3-catalyzed C–H [3 + 2] annulation of anilines with vinylene carbonate, enabling direct access to structura...
Xue Gong, Lin-Yang Li, Yan Hu et al.· ACS Catalysis· 0 citations
Cannabidiol (CBD) is a non-intoxicating phytocannabinoid that has attracted interest as a multi-target neurotherapeutic candidate for neurodegenerative diseases. CBD is a lipophilic terpenophenolic chemotype whose phenolic redox chemistry, membrane partitioning, cytochrome P450-mediated metabolism, and formulation-depe...
Bing-Xing Zhang, Jiang Nan, Yun-Fei Zhang et al.· European journal of medicina...· 0 citations
β-4′-Hydroxymethyl-deleted nucleosides are a class of four-carbon-sugar isonucleosides that possess significant research value in medicinal chemistry and artificial genetic polymer science. Nevertheless, current synthetic methodologies are hampered by several drawbacks, including poor diastereoselectivity, considerable...
