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Author

Jiang-Hua Li

2 papers indexed here

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Review Oct 2026

Engineering microbial platforms for diversified biosynthesis of antidepressant tryptophan-derived neuroactive compounds.

Tryptophan-drived neuroactive compounds, including serotonin, melatonin, 5-hydroxytryptophan (5-HTP), psilocybin, and related indole derivatives, represent an important class of therapeutics for depression and other neuropsychiatric disorders. However, conventional production through chemical synthesis or natural extra...

Rui-Rui Xu, Feng-Ling Yang, Lu-Yao Zhang et al. · 0 citations
#protein folding Oct 2026

Constructing nucleoside deaminase-assisted orthogonal DNA replication system for continuous evolution in prokaryotes.

Orthogonal DNA replication system-based continuous evolution enables user-defined genes to undergo a hypermutagenic evolutionary state through a replication process independent of the host genome, while maintaining overall cellular stability. However, its application is constrained by the relatively low mutation rate o...

Wei-Ran Chu, Rong-Zhen Tian, Ya-Xin Guo et al. · 0 citations

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