Author

Jiang-Hao Yu

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Open access Sep 2026

Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1‐Mediated DNA Damage Repair and PI3K/AKT Survival Signaling

Lung cancer remains a leading cause of cancer‐related mortality worldwide, necessitating the development of novel therapeutic strategies. Matrine, a natural alkaloid derived from Sophora flavescens, has demonstrated broad antitumor properties, yet its underlying mechanisms, particularly concerning DNA damage response,...

Jiang-Hao Yu, Si-Yang Chen, Ting-Ting Hou et al. · Thoracic Cancer · 0 citations

Review Open access Sep 2026

Neuroinflammation and metabolic reprogramming in Parkinson’s disease

An integrative model in which neuroinflammation and metabolic dysfunction function not merely in parallel, but as mutually reinforcing components of a self-amplifying pathological circuit is proposed, while acknowledging that this model remains to be fully validated and that alternative causal architectures are possibl...

Yi-Xin Fu, Jiang-Hao Yu, Lu Xu et al. · Frontiers in Immunology · 0 citations