PODXL regulates the neuronal entry of α-synuclein aggregates
Cell-to-cell transmission of α-synuclein (α-Syn) aggregates is a key event in Parkinson’s disease (PD) pathogenesis, yet the neuronal surface factors that govern uptake of pathogenic α-Syn fibrils remain undefined. We developed a flow cytometry-based CRISPR activation screen for modifiers of α-Syn preformed fibril (PFF...