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Author

Jianan Jiang

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Aug 2026

Comparison of bortezomib with dexamethasone and thalidomide with dexamethasone in the treatment of patients with monoclonal immunoglobulin deposition disease.

Bortezomib/dexamethasone followed by autologous stem cell transplantation is recommended for transplant-eligible patients, while bortezomib/dexamethasone alone remains effective for those who are ineligible, which supports bortezomib/dexamethasone as first-line therapy.

Jianan Jiang, Wen-Cui Chen, Xiaomei Wu et al. · 0 citations
Open access Aug 2026

TOPORS Deficiency Impairs TET2 SUMOylation leading to aberrant m5C Hypermethylation that promotes adipogenic differentiation of mesenchymal stem cells in osteoporosis

Findings establish TOPORS as a key modulator of MSC fate and reveal a mechanistic link between protein SUMOylation and RNA m5C regulation in skeletal homeostasis, supporting a previously unrecognized regulatory role of TOPORS in osteoporosis.

Yi-Bin Zhang, Guangqi Tian, Yun-Hui Zhang et al. · 0 citations

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