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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Jian-Yu Liu

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2 papers indexed here

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Sep 2026

PARP1-targeting PROTAC attenuates alcohol-associated liver injury and ileal epithelial damage.

Alcohol-associated liver disease (ALD) is driven by oxidative stress, inflammation, hepatocyte death, and intestinal barrier disruption, yet targeted pharmacological options remain limited. Here, we investigated LB23, a proteolysis-targeting chimera designed to degrade poly (ADP-ribose) polymerase 1 (PARP1), in cellula...

Qian-Yuan Gong, Jian-Yu Liu, Hua-Cui Li et al. · 0 citations
Open access Sep 2026

Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling

The findings support further investigation of BET/BRD4-associated pharmacological strategies in ESCC, while target-specific validation and expanded in vivo mechanistic and safety studies remain warranted.

Chun-Lan Pu, Jian-Yu Liu, Heng-Rui Fan et al. · 0 citations

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