The GNPS (Global Natural Products Social Molecular Networking) strategy enable the targeted isolation of eremophilane sesquiterpenoids from Penicillium roqueforti, a fungus isolated from the rhizosphere soil of Hypericum beanii N. Robson collected in the Shennongjia Forestry District, Hubei Province, China. The isolate...
Shu-Yuan Mo, Xiang-Man Shu, Jie Zhao et al.· Phytochemistry· 0 citations
A series of novel isatin derivatives synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CLpro were strong inhibitors of SARS-CoV-2 3CLpro.
Jian Song, Cai Shi, Bo-Ning Yang et al.· Journal of Enzyme Inhibition...· 0 citations
Estrogen receptor α (ERα) remains a pivotal therapeutic target for ER-positive (ER+) breast cancer, yet resistance to endocrine therapies driven by ligand-binding pocket (LBP) mutations demands novel strategies. To integrate the complementary strengths of binding modalities of the orthosteric LBP and the allosteric coa...
Chao Wang, Bin Xu, Lilan Xin et al.· Journal of Medicinal Chemist...· 0 citations
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