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Author

Ji’an Yang

3 papers indexed here

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Sep 2026

GNPS-guided discovery of eremophilane sesquiterpenoids from Penicillium roqueforti and their phytotoxic activities.

The GNPS (Global Natural Products Social Molecular Networking) strategy enable the targeted isolation of eremophilane sesquiterpenoids from Penicillium roqueforti, a fungus isolated from the rhizosphere soil of Hypericum beanii N. Robson collected in the Shennongjia Forestry District, Hubei Province, China. The isolate...

Shu-Yuan Mo, Xiang-Man Shu, Jie Zhao et al. · 0 citations
Open access Sep 2026

Exploring novel isatin derivatives as SARS-CoV-2 3CLpro inhibitors

A series of novel isatin derivatives synthesised by incorporating phenyl, biphenyl, naphthyl and indolyl moieties into the N-1 position and screened in vitro against SARS-CoV-2 3CLpro were strong inhibitors of SARS-CoV-2 3CLpro.

Jian Song, Cai Shi, Bo-Ning Yang et al. · 0 citations
Jul 2026

A Novel Dual-Targeting PROTAC Overcomes Endocrine Resistance by Engaging Orthosteric and Allosteric Sites of Estrogen Receptor α.

Estrogen receptor α (ERα) remains a pivotal therapeutic target for ER-positive (ER+) breast cancer, yet resistance to endocrine therapies driven by ligand-binding pocket (LBP) mutations demands novel strategies. To integrate the complementary strengths of binding modalities of the orthosteric LBP and the allosteric coa...

Chao Wang, Bin Xu, Lilan Xin et al. · 0 citations

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