Open access
Jul 2026
Oncolytic virus OHSV2 induces pyroptosis in bladder cancer cells via the TLR4/NLRP3/Caspase-1/GSDMD pathway
A novel TLR4/NLRP3/Caspase-1/GSDMD axis is elucidated as the core mechanism behind the antitumor effect of OHSV2 and a rationale for its combination with immunomodulators to improve outcomes in bladder cancer is proposed.
Jin-Zhou Xu, Yifan Xiong, Chen-Qian Liu et al.
· Molecular Biomedicine · 0 citations