Berberine Prevents and Reverses Gastric Spasmolytic Polypeptide-Expressing Metaplasia by Modulating M2 Macrophage Polarization
Findings provide preclinical evidence supporting berberine as a candidate therapeutic agent for SPEM by preventing and reversing tamoxifen-induced gastric SPEM by inhibiting M2 macrophage polarization and infiltration and regulating the JAK-STAT/NF-κB pathway and S100A6 expression.