Open access
Sep 2026
Intradiscal Delivery of Notoginsenoside R1‐Loaded PLGA Nanoparticles Attenuates Intervertebral Disc Degeneration in Rats
Intervertebral disc degeneration (IVDD) contributes to persistent low back pain, but existing treatments focus on symptom relief rather than addressing the degeneration. Notoginsenoside R1 (NR1), a bioactive saponin derived from Panax notoginseng, has exhibited protective effects in experimental models of disc injury....
Bai-Chuan Zheng, Hao-Tian Zhong, Zheng-Wei Wang et al.
· Journal of Cellular and Mole... · 0 citations