Jian-Wei Xu

MAPK3 as a ferroptosis driver in excitatory neurons in Alzheimer’s disease: from genetic causal inference to in vivo functional validation

Introduction Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and ferroptosis-an iron-dependent form of regulated cell death-has been increasingly implicated in AD-related neuronal loss. However, the causal relationship between specific ferroptosis-related genes and AD, particularly within defined...

Identification of Transcriptome-Derived Candidate Genes Associated with Post-Translational Modification Gene Sets in Neonatal Hypoxic-Ischemic Encephalopathy

Combined treatment of spinal cord injury using channeled Porous-GelMA scaffold loaded with genetically engineered MSCs expressing inducible ChABC and constitutive BDNF

In vivo studies showed that the BDNF/ChABC-MSCs–CPGS integrated system significantly improved BBB scores, markedly reduced lesion size and collagen deposition, and increased expression of the axonal regeneration markers, NF-H and GAP43, thereby promoting axonal regeneration and functional recovery.

Reverse Network Pharmacology-Based Identification of 20-Hydroxyecdysone and Its Inhibition of Glioblastoma Malignant Phenotypes Through the PI3K/AKT Pathway.

BACKGROUND Glioblastoma is the most aggressive primary malignant brain tumor of the central nervous system and remains difficult to treat because of rapid progression, diffuse invasion, and frequent recurrence. This study aimed to identify a potential natural compound against glioblastoma using a reverse network pharma...