Phlorizin, a major apple-derived dihydrochalcone glycoside, has been reported to contribute to metabolic and inflammatory regulation and has been linked to alterations in the gut microbiota across various disease models, but its relationship with the gut microbiota under normal physiological conditions remains uncl...
Yun-Ting Zhang, Mei-Hui Cheng, Si-Qian Chen et al.· Food Science and Human Welln...· 0 citations
The long-standing challenge of seasonal influenza vaccines providing poor protection is attributed to the rapid and continuous evolution of the virus. In theory, the recommendation of vaccine strain is to predict the dominant strain with best fitness in the upcoming season. Here, we develop FutureFlu, a biologically-gr...
Lu-Yao Qin, Meng-Yi Zhang, Xiao-Yuan Liu et al.· bioRxiv· 0 citations
A mechanistic pathway by which EV-A71 co-opts MATR3 through condensate formation and palmitoylation to stabilize its genomic RNA and promote viral replication is delineated, and a comprehensive profiling dataset of host proteins associated with EV-A71 RNA is provided.
Xiaoyan Zuo, Yong-Jun Chen, Xia Xiao et al.· Proceedings of the National...· 0 citations
An integrative host-directed drug discovery framework combining functional genomics and pharmacotranscriptomics is developed, providing a systematic and scalable strategy for discovering antivirals that are less susceptible to resistance and potentially applicable to other rapidly evolving pathogens.
Jianfa Qiu, Xuecong Xing, Jing-Feng Wang et al.· iScience· 0 citations
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