AGTR1 inhibits pyroptosis and inflammatory cytokine secretion in rheumatoid arthritis fibroblast-like synoviocytes through the TGF-β pathway.
BACKGROUND Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease. The hyperactivation of fibroblast-like synoviocytes (FLS) is a major contributor to synovial hyperplasia and cartilage destruction, and FLS pyroptosis plays a pivotal role in RA pathogenesis. This study aimed to investigate the mechanism...