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Open access Sep 2026

VGLL4 enhances PDK4 transcription and promotes metabolic dysfunction-associated fatty liver disease.

MAFLD is a global epidemic with a limited number of approved targeted therapies, underscoring the urgent need to define its underlying regulatory mechanisms. Here, we identify VGLL4 as a positive regulator of MAFLD progression. Hepatocyte-specific overexpression of Vgll4 induces hepatic steatosis, insulin resistance, a...

Yi-Xing Chen, Xiao-Dong Wang, Wen-Tao Yu et al. · 0 citations
Open access Aug 2026

Madecassic acid attenuates sepsis-associated acute lung injury by regulating the PI3K/AKT/mTOR pathway to mediate anti-inflammatory, antioxidant and anti-apoptotic effects.

BACKGROUND Sepsis-induced acute lung injury (ALI) is a critical illness with a high mortality rate. Madecassic acid (MA), a pentacyclic triterpenoid extracted from Centella asiatica, exhibits multiple biological activities, but its role in sepsis-associated ALI remains poorly elucidated. OBJECTIVES The aim of this st...

Zhen Han, Qian Zhang, Bo Cai et al. · 0 citations

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