Alzheimer's disease (AD) is regarded as a multifactorial disease that combines central pathological changes and peripheral organ dysfunction. Its core features include Aβ protein deposition, tau protein pathology, synaptic dysfunction, and neuroinflammation. Exercise has been proven to be one of the most effective non-...
Chang-Jian Wan, Fu-Rui Wang, Yan-Yu Fan et al.· Experimental Neurology· 0 citations
A systematic review systematically delineates the molecular framework of the Parkin‑CMA‑NLRP3‑PANoptosis signaling axis and summarizes translational progress of small‑molecule compounds and gene therapies targeting individual components within this cascade.
Xing-Hua Tian, Biao Zhang, Yu Wang et al.· Progress in neurobiology· 0 citations
Preclinical findings indicate that Ace2 deficiency is associated with concurrent pathological abnormalities in the brain and transient bone metabolic disturbance under short-term MPTP treatment in growing young male mice, consistent with a potential bone-brain axis pathological phenotype.
Ting-Ting Liu, Yu-Heng Ren, Xinghua Tian et al.· Zeitschrift für Induktive Ab...· 0 citations
Impaired myelin integrity and defective myelin regeneration represent core pathological features shared by central nervous system (CNS) diseases, such as multiple sclerosis (MS), Alzheimer's disease (AD), ischemic cerebral white matter lesions and spinal cord injury (SCI). Triggering Receptor Expressed on Myeloid Cells...
Ze-Hao Zhang, Wen-Jing Zhang, Long Jin et al.· Cellular Signalling· 0 citations
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