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Jian-Qing Zheng

2 papers indexed here

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Open access Oct 2026

ClonoDeconv: reference-based α − β paired recurrent clonotype proportion estimation from bulk-TCR sequencing

T cell receptor (TCR) sequencing is crucial when studying antigen-specific T cell responses and clonal dynamics. A key objective of TCR repertoire analysis is to identify recurring clonotypes across timepoints or different disease states, providing insight into the evolution of immune response. Bulk-TCR sequencing enab...

Yu-Ze Zhou, E. Antoun, M. Pinho et al. · 0 citations
#artificial intelligence Preprint Oct 2026

Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families

Discovering broadly neutralizing antibodies (bnAbs) from human natural immune repertoires remains a fundamental challenge in immunology, hindered by: the extreme rarity of bnAb, incomplete understanding of their cellular origins across pathogens, and the inability of existing computational tools to generalize across em...

Hantao Lou, Jian-Qing Zheng, Can Yue et al. · 0 citations

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