Author

Jian-Qing Lin

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Open access Sep 2026

Spatial habitat radiomics predicts tertiary lymphoid structure status and identifies an IDO1+ migratory dendritic cell axis in breast cancer

Abstract Background Tertiary lymphoid structures (TLS) are spatially organized immune niches associated with therapeutic response and favorable outcomes in breast cancer (BC). However, TLS assessment currently relies on invasive tissue-based analyses, and the biological mechanisms underlying imaging-based TLS predictio...

Yu-Shuai Yu, Qing Wang, Yi-Dan Lin et al. · Journal for ImmunoTherapy of... · 0 citations

Open access Oct 2026

NR3C2 suppresses triple-negative breast cancer progression by regulating mitochondrial ROS homeostasis via NDUFB3

Highlights • NR3C2 expression is significantly decreased in triple-negative breast cancer and is associated with poor prognosis.• NR3C2 suppresses TNBC cell proliferation and migration both in vitro and in zebrafish xenograft models.• Transcriptomic analysis identifies NDUFB3 as a potential downstream target of NR3C2.•...

Hai-Hong Shi, Xiang-Rui Zeng, Qiao-Nan Guo et al. · Translational Oncology · 0 citations