Jian-Nan Chen

The preventive effects of tetrahydroberberine on male obese mice and its uptake by adipocytes are associated with the D2R-PI3K axis and OCT2.

Obesity arises from a chronic imbalance between energy intake and consumption that culminates in pathological adipose tissue expansion, ectopic lipid deposition, and persistent low-grade inflammation. Tetrahydroberberine, the principal reductive metabolite of berberine, exhibits potent lipid-lowering and fat-targeting...