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Author

Jian-Min Wang

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Review Open access Oct 2026

Single-cell and spatial transcriptomics in intrahepatic cholangiocarcinoma: spatial immune ecosystems, metabolic remodeling, and immunotherapeutic implications

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy characterized by pronounced cellular, spatial, and metabolic heterogeneity. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are beginning to resolve this complexity by linking malignant, immune, stromal, and metabolic state...

Ya-Nan Yan, Tian-Hao Teng, Xin-Ying Luo et al. · 0 citations
Open access Aug 2026

FTU-Seek: Foundation Model-Guided Hard-Negative Learning for Sparse Functional Tissue Unit Segmentation

Background/Objectives: Functional tissue units (FTUs), including tertiary lymphoid structures (TLSs), blood vessels, and glands, encode localized immune, vascular, and epithelial organization in histopathology. Accurate quantification of these structures is important for studying tissue architecture and disease-associa...

Zong-Hao Liu, Lei Su, Ji-Guang Yu et al. · 8 citations

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