This paper introduces Caduceus, a family of MoE-enhanced foundation models built with a hierarchical pre-training paradigm to jointly integrate biological and natural language, and incorporates a multi-task instruction tuning phase, enabling robust protein parsing and natural language question answering.
Ming-Ze Yin, Yiheng Zhu, Jialu Wu et al.· Proceedings of the 32nd ACM...· 1 citation
IgGM2 follows a structure-to-design strategy: it first learns how immune receptors are positioned around fixed target structures, and then transfers this target-conditioned structural prior to CDR design, allowing frame-work geometry to adapt to designed CDRs without separate inverse folding or external sidechain packi...
Jian Ma, Fandi Wu, Lin Yao et al.· bioRxiv· 0 citations
This paper introduces Caduceus, a family of MoE-enhanced foundation models built with a hierarchical pre-training paradigm to jointly integrate biological and natural language, and incorporates a multi-task instruction tuning phase, enabling robust protein parsing and natural language question answering.
Mingze Yin, Yiheng Zhu, Jialu Wu et al.· Proceedings of the 32nd ACM...· 0 citations
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