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Jianjun Yang

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Open access Sep 2026

Dexmedetomidine Attenuates Sepsis-Associated Inflammation and Encephalopathy by Modulating the MeCP2/NLGN1 Pathway.

PURPOSE Sepsis-associated encephalopathy (SAE) is a common and serious complication in septic patients that significantly reduces quality of life. Besides its sedative and analgesic effects, dexmedetomidine has been suggested to have potential neuroprotective benefits. This study aims to determine whether dexmedetomidi...

Bo-Wen Hu, Yu-Ge Wang, Ying Yang et al. · 0 citations
Aug 2026

Isolinderalactone alleviates hepatic ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress through the SIRT1/IRE1α signaling pathway.

ILL attenuates HIRI by simultaneously elevating SIRT1 expression and activating its deacetylase function, thereby restraining IRE1α-dependent ERS and subsequent hepatic injury, highlighting ILL as a promising therapeutic candidate for the management of perioperative HIRI.

Hao Li, Zhen-Yu Guan, Wendong Li et al. · 0 citations

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