Macrophages and microglia serve as both "scavengers" and "immune sentinels" to maintain tissue homeostasis. However, when the lipid load exceeds their processing capacity, these cells transform into foam cells, thereby driving chronic inflammation and impairing tissue repair. Despite their distinct organ systems, ather...
Gui-Na Tan, Xiao-Xin Wang, Jing Chen et al.· Journal of Lipid Research· 0 citations
Platelet-rich plasma (PRP), an autologous blood derivative rich in multiple growth factors and cytokines, has shown broad application prospects in the field of tissue repair and regeneration. In recent years, the therapeutic potential of PRP in neurological disorders has gained increasing attention. This article system...
Gui-Na Tan, Xiao-Xin Wang, Jing Chen et al.· Frontiers in Immunology· 0 citations
Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a highly conserved deubiquitinating enzyme that has transitioned from being viewed as a “brain‐specific” protein to a global regulator of cellular proteostasis and signal transduction. As a key component of the ubiquitin‐proteasome system (UPS), UCHL1 maintains the intracell...
Ru Feng, Xiu Zhong, Jianjun Li et al.· Immunology and Cell Biology· 0 citations
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