Author

Jian-Hui Wang

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Sep 2026

Mapping cell-type- and age-dependent neuronal vulnerability through genome-wide in vivo CRISPRi screens in the mouse brain.

A scalable, cell-type-resolved in vivo CRISPR interference (CRISPRi) platform enabling systematic gene function profiling in the mouse brain is developed and the CRISPRinvivo data portal is established as a community resource for in vivo screening.

Risheng Lin, Ze-Ting Ke, Jian-Hui Wang et al. · Neuron · 0 citations

Open access Jul 2026

A pooled CRISPR-based neuronal activity screen links TMEM50A-dependent MVB function to synaptic integrity and remote memory.

A high-throughput functional genomics platform that couples the calcium-integrating sensor CaMPARI2 with CRISPRi screening in human iPSC-derived neurons is established and reveals a critical role for TMEM50A-dependent MVB function in maintaining synaptic integrity and behavior.

Jian-Hui Wang, Meiqi Liu, Yi-Ming Chen et al. · Cell Reports · 0 citations