Author

Jian-Hua Zou

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Sep 2026

HCE6-mediated photodynamic therapy induces hepatocellular carcinoma cell death via inhibition of autophagic flux.

Porphyrin derivatives are potential candidates for photodynamic therapy against cancer. In this study, hydrophilic chlorin e6 trisodium salt (HCE6) was selected for treatment of hepatocellular carcinoma (HCC). SK-hep1 cells and a xenograft mouse model were used to investigate the antitumor efficacy and the autophagic m...

Xin Jiang, Ke-Yi Zhou, Xin-Tian Huang et al. · Journal of materials chemist... · 0 citations

Open access Sep 2026

Carrier-free nanomodulators reprogramming acetate metabolism for cancer photo-immunotherapy via c-Myc inhibition-induced closed-loop regulatory circuit

Non-small cell lung cancer (NSCLC) remains difficult to cure owing to therapy resistance and immune evasion that limits durable therapeutic responses. Here, we report a carrier-free nanoregulator (CE NPs) formed by co-assembling chlorin e6 (Ce6) with a covalent c-Myc inhibitor (EN4), enabling photo-immunotherapy that c...

Jian-Wei Zhu, Dan-Ming Dong, Jia-Yue Xu et al. · Materials Today Bio · 0 citations