Jian-Hua Luo

Scalable Total Syntheses of Nonthmicin and Ecteinamycin Reveal a Dual Antibacterial and Antitoxin Profile against Clostridioides difficile

Clostridioides difficile infection (CDI) is a severe diarrheal disease with substantial mortality, frequent recurrence, and limited treatment options. Here, we describe a scalable total synthesis of ecteinamycin, a polyether ionophore with anti-C. difficile activity, and its congener nonthmicin. Key steps include two...