Aug 2026
Probing the Catalytic Promiscuity and Enhancing the Efficiency of CYP725A4 with a Taxadiene Substrate Mimic
The catalytic promiscuity of cytochrome P450 CYP725A4 severely impedes paclitaxel biosynthesis, as it generates taxadien-5α-ol (T-5α-ol) alongside numerous by-products. Despite diverse proposed mechanisms and the reported role of facilitator of taxane oxidation (FoTO1) in promoting T-5α-ol formation, conclusive evide...
Long-Hao Huang, Ming-Yuan Lai, Zi-Han Zhang et al.
· ACS Catalysis · 0 citations