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Review Sep 2026

Powering the liver toxicity assessment in the organoid era.

Hepatotoxicity assessment is paramount in drug development and food safety. Traditional in vitro models suffer from insufficient physiological relevance and poor functional reproducibility. Liver organoids have rapidly emerged as three-dimensional culture models capable of recapitulating multicellular interactions and...

Xin-Lan Yu, Ling Shen, Xianchao Zhou et al. · 0 citations

Digital twins in medicine: Future horizons

Virtual patients have advanced from proof-of-concept to pragmatic tools in precision medicine, yet their role must be recalibrated. This Perspective argues that virtual patients should function not as substitutes for human participants, but as ethically governed auxiliary systems for addressing data scarcity, high-dime...

Meng-Bi Shen, Shi-Yu Du, Jian He · 0 citations

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