Antibiotic-resistant tuberculosis remains a major public health challenge, and rapid diagnosis of resistant infections based on genomic markers holds promise for improving time to effective treatment. However, the vast majority of clinically observed variants in resistance-associated genes remain of uncertain significa...
Mahbuba Tasmin, Shrishti Barethiya, Yu Wang et al.· bioRxiv· 0 citations
DNA is a fundamental biomolecule in eukaryotic cells, playing central roles in processes ranging from genome organization and transcription to innate immune signaling. Recent studies have revealed that DNA can undergo protein-free phase separation in the presence of divalent cations, yet the underlying molecular mechan...
Investigating the conformational dynamics of intrinsically disordered proteins (IDPs) is essential to understanding how their structural heterogeneity underlies function and how their dysregulation contributes to diseases. Here, we utilized an MspA nanopore-based approach for studying the conformational dynamics and in...
David DeCoeur, Samantha A Schultz, Jianhan Chen et al.· bioRxiv· 0 citations
The spatial distribution of small molecules within cells shapes their biological activity, yet these distributions are generally assumed to be governed passively by reaction-driven electrochemical gradients. Here we show that aminoglycoside antibiotics actively control their own subcellular organization by undergoing p...
Yuefeng Ma, Wen Yu, E. Moon et al.· bioRxiv· 0 citations
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