Jianchun Bian

Co-exposure to deoxynivalenol and hexavalent chromium is associated with intestinal injury, dysbiosis, and activation of ferroptosis and pyroptosis related pathways in broilers.

The combined pollution of deoxynivalenol (DON) and hexavalent chromium [Cr(VI)] during crop and food processing poses a serious threat to the intestinal health of poultry and humans. However, the specific regulatory mechanisms underlying intestinal toxicity induced by DON and Cr(VI) co-exposure in broilers remain uncle...

Polystyrene nanoplastics potentiate cadmium-induced pyroptosis and apoptosis in primary duck hepatocytes: differential responses to N-acetylcysteine

Nanoplastics (NPs) can act as carriers for heavy metals, and co-exposure to NPs and co-pollutants may produce greater toxicity than single exposure. However, the combined toxicity of nanoplastics and heavy metals in poultry liver cells remains poorly understood. Primary duck embryonic hepatocytes (PDEH) we...

SLC25A39: A Guardian against Cadmium-Induced Pleiotropic Disruption of Mitochondrial Homeostasis in Rat Neuronal Cells.

Cadmium (Cd) is a neurotoxic heavy metal, and mitochondrial homeostasis disruption is a key mechanism underlying its neurotoxicity. SLC25A39, a mitochondrial transporter, maintains the mitochondrial homeostasis. This study investigated the role of SLC25A39 in the Cd-induced disruption of mitochondrial homeostasis in ra...

Coexistence and combined toxic effects of principal emerging and common mycotoxins