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Author

Jian‐Bo Tong

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2 papers indexed here

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Open access Oct 2026

Design of Novel PI4KIIIβ Inhibitors Based on QSAR, Molecular Docking, and Molecular Dynamics Simulations

Phosphatidylinositol 4‐kinase IIIβ (PI4KIIIβ) is a key enzyme responsible for catalyzing the production of phosphatidylinositol 4‐phosphate (PI4P). It plays a central role in regulating physiological and pathological processes, including membrane transport, signal transduction, and pathogen infection. Recently, abe...

Rong Wang, Jian-Bo Tong, Yue Sun et al. · 0 citations
Aug 2026

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms.

Sophoridine is a quinolizidine-type natural alkaloid with favorable structural modifiability and diverse biological activities. However, the pharmacological potential of sophoridine derivatives originally optimized for insecticidal activity remains largely unexplored. Here, a bioactivity repurposing strategy was applie...

Ya-Kun Zhang, Jian‐Bo Tong, Hong-Yan Zhang et al. · 0 citations

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