Jul 2026
Machine-Learning-Enabled Rapid Evolution of Photoenzymes for the Asymmetric Synthesis of gem-Difluorophosphonates.
A small-sample, accelerated evolution strategy that integrates focused rational iterative site-specific mutagenesis (FRISM) with the EVOLVEpro model is reported, providing a robust, "lightweight" machine learning framework for the rapid development of new-to-nature photoenzymatic transformations.
Hongkui Wang, Jiafan Xu, Jiahai Zhou et al.
· Angewandte Chemie · 0 citations