Aug 2026
Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.
It is reported that mutant p53 rescued by ATO treatment strengthened interferon responses triggered by the DNA hypomethylating agent decitabine by transactivating interferon regulatory factor 7 (IRF7) directly.
Huaxin Song, Xin-Jie Chen, Shujun Xiao et al.
· Science Translational Medici... · 1 citation