γδ T cells are a unique lymphocyte lineage that bridges innate and adaptive immunity through MHC-unrestricted recognition of phosphoantigens, lipids, and stress-induced proteins. Their tissue-resident subsets, shaped by Vγ/Vδ chain usage, play essential roles in barrier surveillance, tissue homeostasis, and host defens...
Jiacheng Lou, N. Zou· Frontiers in Immunology· 0 citations
This review synthesizes preclinical and clinical evidence on daraxonrasib and related RAS(ON) inhibitors across RAS-mutant malignancies and provides a comprehensive framework for understanding the promise and challenges of pan-RAS inhibition in precision oncology.
Jiacheng Lou, Dan Zhang· Experimental Hematology & On...· 0 citations
Protein farnesylation, catalyzed by farnesyltransferase (FTase), covalently attaches a 15-carbon farnesyl lipid to cysteine residues within C-terminal CaaX motifs. This modification governs the subcellular localization, protein–protein interactions, and activity of diverse eukaryotic proteins, including Ras GTPases, nu...
Jiacheng Lou, Dan Zhang, Ying-Jie Wang· Frontiers in Pharmacology· 0 citations
All-trans retinoic acid (ATRA) is a potent differentiation inducer successfully used to treat acute promyelocytic leukemia (APL), with its therapeutic efficacy traditionally attributed to targeting the PML/RARα fusion oncoprotein. ATRA also exhibits anti-tumor activity in multiple non-APL malignancies. However, PML/RAR...
W. Jin, Peng Jin, Yun Tan et al.· Biochemical Pharmacology· 0 citations
This review comprehensively summarizes recent clinical advances of antibody–drug conjugates and bispecific antibodies across both hematologic malignancies and solid tumors and provides a roadmap for translating antibody‑based innovations into precision oncology.
