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Jia-Yu Yan

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Aug 2026

p21 Inhibition Rescues Radiation-Induced Osteogenic Dysfunction and Promotes Bone Regeneration in Osteoradionecrosis of the Jaw via the Rb-Smad2/3-Runx2 Axis.

BACKGROUND Osteoradionecrosis of the jaw (ORNJ) is a severe radiotherapy complication with unclear molecular drivers. CDKN1A/p21 is upregulated by radiation-induced DNA damage, but its role in ORNJ remains unknown. METHODS An ORNJ mouse model was established. Single-cell RNA-sequencing of irradiated mandibles was ana...

Jia-Ying Shi, Shu-Xian Lin, Jia-Yu Yan et al. · 0 citations

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