Author

Jia-Yin Yue

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Sep 2026

Investigating the anti-TNBC potential of new quinazoline-based PAK4 inhibitors: design, synthesis and biological evaluation.

Results validate 11j as a promising lead for TNBC therapy, especially in combination with EGFR-targeted agents.

Shuang Hao, Yi-Fan Niu, Meng Si et al. · European journal of medicina... · 0 citations

Open access Jul 2026

Proposed Allosteric Inhibition of Cyclin-Dependent Kinase 4 by a Proline-Derived Acylsemicarbazide Compound with Antiproliferative Activity in Breast Cancer Cells

The identified conformational mechanism provides new insights into the dynamic regulation of CDK4 and suggests that stabilization of transient allosteric states represents a promising strategy for the rational design of next-generation CDK4 inhibitors with the potential to overcome resistance in breast cancer therapy.

Xu Huang, Qing-yang Nian, Xi-Zhe Sun et al. · Pharmaceuticals · 0 citations