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Jia-Yi Zhang

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Open access Sep 2026

Identification of rs28362336 as a risk SNP for generalized myasthenia gravis and its impact on HCG27 regulation

Myasthenia gravis (MG) is an antibody-mediated autoimmune disease of the neuromuscular junctions. Accumulating amounts of evidence have indicated that single nucleotide polymorphisms (SNPs) and long noncoding RNAs (lncRNAs) play critical roles in the pathogenesis of MG; however, research on MG-related lncRNA SNPs remai...

Zi-Hong Chen, Qing-Ling Guo, Li-Ting Tian et al. · PLoS ONE · 0 citations

Open access Aug 2026

Interpretable machine learning identifies immune-inflammatory and immunothrombotic biomarkers for myocardial injury and mortality risk stratification in severe pneumonia with diverse infectious etiologies

Background Severe pneumonia is frequently associated with dysregulated immune-inflammatory responses and immunothrombotic activation, contributing to myocardial injury and adverse clinical outcomes. Early identification of patients at high risk for myocardial injury and mortality across varied infectious etiologies rem...

Yi-Cheng Wang, Feng Li, Tian-Qiang Yan et al. · Frontiers in Cellular and In... · 0 citations

Aug 2026

Single-cell transcriptomic analysis reveals systemic immune dysregulation and identifies PLEK as a candidate hub gene associated with CD8+ T-cell activation in myasthenia gravis.

This study provides a systems-level view of immune dysregulation in MG, highlighting enhanced intercellular communication, T-cell dysregulation, and PLEK as a potential molecular marker associated with CD8+ T-cell activation and disease severity, offering insights into MG pathogenesis and therapeutic targets.

Jing-Nan Jin, Zi-Hong Chen, Yi-Ying Zhang et al. · Journal of Neuroimmunology · 0 citations